Open Standards for Reproducible Science
MOSSDO publishes freely accessible standards, white papers, and technical reports developed through community consensus. All documents are available for download without registration.
Ratified Standards
Minimum Reporting Requirements for Organ-on-Chip Studies
Defines the minimum set of experimental parameters, device specifications, and biological readouts that must be reported in publications describing organ-on-chip studies to enable reproducibility.
Terminology Standard for Microphysiological Systems
Establishes a controlled vocabulary and definitions for terms used in microphysiological systems research, including organ-on-chip, body-on-chip, organoid, and related concepts.
Data Reporting Format for MPS Experimental Results
Specifies a structured data format and metadata schema for reporting experimental results from microphysiological systems studies, designed to support data sharing and meta-analysis.
Biomaterial Characterization Requirements for Organoid Scaffolds
Defines characterization methods and reporting requirements for hydrogels, synthetic scaffolds, and extracellular matrix components used in organoid and MPS culture systems.
Validation Framework for MPS-Based Toxicology Assays
Provides a framework for validating organ-on-chip and organoid-based toxicology assays, including criteria for assay qualification, performance benchmarks, and inter-laboratory comparison.
Imaging and Phenotyping Standards for Organoid High-Content Analysis
Establishes standards for microscopy acquisition parameters, image analysis pipelines, and phenotypic readout reporting in high-content organoid screening applications.
Regulatory Submission Guidelines for MPS-Derived Safety Data
Guidance for preparing and submitting safety data generated from microphysiological systems to regulatory agencies, including recommended formats and supporting documentation.
Draft Standards
Draft standards are open for community comment before ratification. All researchers are encouraged to review and submit feedback.
Organ-on-Chip Terminology Supplement: Vascularized and Multi-Organ Systems
An extension to MOSSDO-002 addressing terminology for vascularized organ-on-chip devices, multi-organ body-on-chip platforms, and integrated fluidic interconnects.
AI-Assisted Organoid Analysis: Minimum Reporting Requirements
Defines minimum reporting requirements for studies using machine learning or AI-based tools for organoid image analysis, phenotyping, or drug response prediction.
White Papers & Reports
The Case for Open Standards in Microphysiological Systems Research
An overview of the reproducibility challenges facing the MPS field and the rationale for community-developed, open standards.
Inter-Laboratory Comparison Study: MOSSDO-001 Pilot Implementation
Results from a 14-laboratory pilot study evaluating the feasibility and impact of implementing MOSSDO-001 reporting requirements.
Regulatory Pathways for MPS-Based Evidence: A Landscape Analysis
A survey of current regulatory agency positions on MPS-derived data across FDA, EMA, and PMDA, with recommendations for the field.
MOSSDO Membership Survey: Barriers to Standards Adoption
Findings from the 2025 annual member survey on awareness, adoption, and perceived barriers to implementing MOSSDO standards.
Contribute to the Next Standard
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